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LANDOVER, Md. (AP) -- Marcus Mariota threw three touchdown passes, and Kain Medrano returned an interception 50 yards for a touchdown to help the Washington Commanders hand Seattle its first loss since November, 33-31 on Sunday.
The Seahawks (2-1) had won 12 straight, including their postseason run to last season’s Super Bowl title, but Mariota was solid in place of the injured Jayden Daniels, and three crucial turnovers enabled Washington (1-2) to win its home opener.
Jaxon Smith-Njigba caught 10 passes for 128 yards and two touchdowns for the Seahawks, and he even completed a short throw on a trick play in the final quarter, but Sam Darnold was intercepted twice in his return from his Week 1 glute injury.
After Washington had taken a 27-24 lead, Medrano picked off Darnold’s pass over the middle and ran it back all the way to put the Commanders two scores ahead with 3:57 to play. However, a penalty during the celebration moved the extra point back 15 yards, and Drew Stevens missed it.
GIANTS 12, TITANS 7
EAST RUTHERFORD, N.J. -- Relying on running the ball in their first game without quarterback Jaxson Dart, New York held on to beat Tennessee but lost its most important defensive player, Brian Burns, to a knee injury.
Burns went down grabbing at his right knee midway through the fourth quarter and had to be helped off the field by offensive linemen Andrew Thomas and Aaron Stinnie. Burns played six days after spraining his left ankle in a defeat at the Los Angeles Rams, despite not practicing all week.
If it is significant like Dart’s injury, which has him out for at least the remainder of the regular season, it is another blow to the Giants (2-1) after John Harbaugh’s tenure as coach got off to a promising start. Burns ranked second in the NFL in sacks last season behind record-setter Myles Garrett.
In his first start in place of Dart, Jameis Winston did what he needed to do, completing 12 of 18 passes for 117 yards and scrambling 15 yards for a first down. With a nor’easter pounding the region, Harbaugh and offensive coordinator Matt Nagy kept the ball on the ground on a rainy, windy afternoon, piling up 141 yards rushing and getting four field goals from rookie kicker Dominic Zvada.
JAGUARS 35, PATRIOTS 6
JACKSONVILLE, Fla. -- Trevor Lawrence threw three touchdown passes, including one on which Parker Washington made a fingertip catch in the end zone, and Jacksonville bounced back from its worst offensive performance in nearly a year to dominate New England.
Lawrence also strangely gave himself up at the 1-yard line with nearly 9 minutes to play. It created countless laughs on the sideline. Bhayshul Tuten scored on the next play, which surely will cause angst in the fantasy football world.
Regardless, the Jaguars (2-1) won their sixth consecutive regular-season game at home and raised more questions about Drake Maye’s regression for the Patriots.
Maye fumbled twice, losing one, and threw two more interceptions before getting pulled in the fourth quarter with the game out of reach. He now has one TD pass and six INTs in three games. He threw 31 touchdowns and eight picks last season for the AFC champion Patriots (1-2).
CHIEFS 24, DOLPHINS 10
MIAMI GARDENS, Fla. -- Kenneth Walker III had a touchdown catch and rushed for a score, Patrick Mahomes threw for 246 yards and two TDs, and Kansas City beat Miami.
The Chiefs (3-0) entered averaging more than 450 yards and 32 points but struggled to pull away from the winless Dolphins, who were missing arguably their best player for much of the game after Pro Bowler De’Von Achane left with a knee injury on the opening drive.
Mahomes completed 20 of 24 passes with an interception. He threw a 5-yard touchdown pass to Walker, and his 11-yard TD pass to Travis Kelce put the game out of reach.
Mahomes found Kelce in the end zone with 2:55 left to put the Chiefs up by two scores after Kansas City stopped the Dolphins on fourth down at Miami’s 48. The Chiefs intercepted Malik Willis on the ensuing drive, and Mahomes moved Kansas City into scoring position before Harrison Butker missed a 50-yard field-goal attempt.
LIONS 31, JETS 24
DETROIT -- Jahmyr Gibbs had a go-ahead 11-yard reception with 2:25 left for his third touchdown of the game and Detroit held on to beat New York.
The Lions (2-1) leaned on Gibbs a lot -- on the ground and through the year -- and he delivered another fantastic performance. The dynamic running back had 20 carries for 99 yards with 17- and 1-yard touchdown runs in the second half, along with seven receptions for 65 yards and score.
The Jets (1-2) overcame a 14-point deficit in the fourth quarter with Geno Smith’s 4-yard touchdown pass to Jeremy Ruckert, a 23-yard throw to Garrett Wilson and a 2-point conversion pass to Sterling Shepard to make it 24-all.
New York’s defense -- led by head coach Aaron Glenn, Detroit’s former defensive coordinator -- then had two blown coverages as Goff and Gibbs marched the Lions down the field to quickly regain the lead.
With a chance to tie or perhaps go for the win, the Jets were on the Detroit 28 when Smith lost a fumble after blitzing safety Chuck Clark sacked him. That sealed it for the Lions.
COLTS 19, TEXANS 17
INDIANAPOLIS -- Spencer Shrader fought through a groin injury to make four field goals, including a 43-yarder with 16 seconds to go, and Indianapolis’ beleaguered defense barely held up long enough to close out a victory over Houston.
The Colts (1-2) snapped a nine-game losing streak, the longest active skid in the NFL, and won its first game since Nov. 2 at Berlin. It was the Colts’ first victory on American soil since Oct. 26, 2025.
Daniel Jones was 24 of 36 for 235 yards and one touchdown, but also fumbled three times and lost two. The second set up Houston’s late go-ahead touchdown.
Jonathan Taylor had 23 carries for 68 yards for Indianapolis. Keenan Allen hauled in six passes for 63 yards and his first TD with the Colts, while Josh Downs caught five passes for 77 yards.
Houston is off to its second straight 0-3 start and it was a rugged day for the offense. C.J. Stroud was 16 of 27 for 167 yards with one TD as the Texans finished with just 70 yards on 21 carries and had 223 total yards against a defense that allowed more than 500 yards in each of its first two games. The loss was Houston’s first in the last six games of this series.
RAIDERS 35, SAINTS 27
NEW ORLEANS -- Kirk Cousins passed for 248 yards and three touchdowns, and Las Vegas overcame an 11-point second-half deficit to beat New Orleans and remain unbeaten under rookie coach Klint Kubiak.
The game shifted on a play that will be seen as controversial and unjust by some -- and certainly Saints fans.
The series that led to the Raiders’ go-ahead score began when Las Vegas defensive end Malcolm Koonce sacked Tyler Shough as the Saints QB started his throwing motion.
The ball went backward and was ruled a fumble that was recovered by the Raiders -- a different ruling than was made after a similar play involving the Saints in Week 1 at Detroit. On that play, an apparent New Orleans strip-sack of the Lions’ Jared Goff was ruled incomplete on video review after the Saints thought they had recovered a fumble for a touchdown.
The Superdome crowd booed as officials, following a video review, upheld the call that the play had resulted in a turnover on the New Orleans 45.
Six plays later, Cousins connected with Cody White for a 4-yard touchdown to make it 28-27.
Cousins gave Las Vegas (3-0) an eight-point lead with a 4-yard TD pass to Brock Bowers. The Saints (1-2) got the ball twice more with a chance to tie it, but one drive stalled on fourth down and another on Juwan Johnson’s fumble with 1:02 left.
Shough passed for 255 yards and a career-high four touchdowns -- including two to Johnson. Shough’s other scoring passes went to Noah Fant from short range. But the second-year QB also turned the ball over twice, first on his fumble and later on an interception that set up the Raiders’ final scoring drive.
VIKINGS 23, BUCANEERS 16
TAMPA, Fla. -- Myles Price returned a punt 86 yards for a score, Kyler Murray threw a 41-yard TD pass to Jordan Addison and Minnesota beat Tampa Bay.
It was a costly game for both teams.
Baker Mayfield hurt his thumb on a desperation pass late in the fourth quarter. He was screaming in pain on the ground before walking off and was replaced by rookie Jalon Daniels in the final minute.
Two-time All-Pro wide receiver Justin Jefferson didn’t return for Minnesota after injuring his right ankle in the first quarter.
The Vikings are 3-0 for the second time in three years. The Buccaneers are 0-3 for the first time since 2014, when they finished 2-14 and got the No. 1 overall draft pick, taking Jameis Winston.
Murray was 15 of 29 for 168 yards with one TD pass and one interception in his first full game with the Vikings. He sustained a concussion in the first quarter of the season opener and Carson Wentz led Minnesota to consecutive wins.
49ERS 36, CARDINALS 30
SANTA CLARA, Calif. -- Brock Purdy threw four touchdown passes, with the first coming on a trick play, and the injury-depleted San Francisco held on for a victory over Arizona.
San Francisco lost wide receiver Mike Evans to a rib injury in the first half and left tackle Trent Williams to a stinger in the second half, but still managed to hold on to start 3-0 for the third time in the last four seasons.
The game began well for the Niners before the injuries started mounting and they found themselves in a tight game against the Cardinals (1-2), who have lost 22 of their last 26 games in the division.
Purdy helped ice it when he threw a 20-yard TD pass to George Kittle with 1:31 to play. The Cardinals added a late field goal, but Deebo Samuel recovered an onside kick to seal the win.
Coach Kyle Shanahan dialed up a hook-and-ladder call on San Francisco’s third play from scrimmage to turn a precarious third-and-12 from deep in 49ers territory into an 82-yard score. Purdy threw a quick 6-yard pass to Evans, who flipped it back 4 yards to a sprinting Samuel as he was being tackled well short of the first down. Samuel then sprinted down the sideline, broke a tackle near midfield and scored to make it 7-0 on an 82-yard play.
Purdy then connected on a 23-yard TD pass to Evans on the second drive and the Niners built the lead to 23-6 when Christian McCaffrey scored on a 1-yard run on the opening drive of the second half.
RAVENS 34, COWBOYS 31
RIO DE JANEIRO -- Lamar Jackson completed a 27-yard pass to Zay Flowers and alertly called a timeout with 1 second left, setting up Tyler Loop’s 56-yard field goal to cap a stunning 7-second drive that gave Baltimore a victory over Dallas in Brazil.
The Ravens (2-1) and Cowboys (1-2) put on a entertaining show in front of an announced crowd of 72,792 during the NFL’s third game in Brazil and first in the city of Rio de Janeiro, engaging in a back-and-forth contest that featured plenty of big plays.
For a moment, it looked as though it would be the Cowboys who would win the game in regulation.
Ravens cornerback Nate Wiggins was called for pass interference with 23 seconds left when his arms locked with CeeDee Lamb, giving the Cowboys the ball at the Ravens 2. After an incomplete pass, the Cowboys were called for a false start, which backed them up to the 7. Dallas settled for Brandon Aubrey’s 23-yard field goal.
And that set up the Ravens’ improbable finish that was capped by Loop’s kick sailing through the uprights and the jubilant Ravens swarming their kicker during a wild celebration at the Maracana.