Wednesday saw the greatest single-day increase of new COVID-19 cases in Warren County so far.

The Pennsylvania Department of Health reported 22 new cases.

The previous daily high was 21 (as updated by the Department of Health), on Friday, Nov. 20.

There have now been a reported 194 cases in the county — 171 confirmed and 23 probable.

According to the department’s zip code data, multiple new cases were reported in Warren (10 confirmed, 1 probable), Clarendon (three), and Sheffield (two). Irvine (first case), Russell, Sugar Grove, Bear Lake, and Columbus each had one new confirmed case.

The additional case could have been in one of the zip codes that have at least one, but fewer than five cases, or from one of three zip codes that originate outside of Warren County but include county residents. There were new cases in Corry (three confirmed, three probable), Spartansburg (one), and Titusville (18).

At 491.2, Warren County is the only county in the state with fewer than 500 cases per 100,000 population.

Cameron County has had five new cases in the past two days, bringing its total case count to 23 and its rate to 512 per 100,000.

Philadelphia — 3,669 — Centre — 3,666 — and Huntingdon — 3,606 — are the counties with the highest rates in the state.

Tioga County in north central Pennsylvania, once one of the least positive counties in the state, is now over 2,000 cases per 100,000 population. About one in 50 people there have reportedly had COVID-19.

Tioga has a population of just over 40,000 according to 2018 statistics. Warren County’s population was 39,200 as of 2019 statistics.

On Sept. 28, Tioga County had 70 cases and a rate of 171.70 per 100,000 and Warren County had 43 cases and a rate of 108.9. Since then, Tioga’s numbers have jumped to 832 cases and a rate of 2,041.

There were three COVID-related deaths in Tioga County through July 31 and no more through most of October. There have been eight more deaths there since Oct. 28, bringing that number to 11.

Warren County has had one reported COVID-related death.

On Wednesday, Gov. Tom Wolf renewed the COVID-19 disaster proclamation for the third time.

On Monday, Wolf and Health Secretary Dr. Rachel Levine announced new restrictions and recommendations including some scaled penalties for businesses that violate masking and distancing guidelines.

They also recommended that people who do not live together not gather to celebrate Thanksgiving due to the increased chances of spreading COVID-19.